Home | About PR | Editorial board | Search | Ahead of print | Current Issue | Archives | Instructions | Subscribe | Advertise | Contact us |   Login 
Pharmacognosy Magazine
Search Article 
  
Advanced search 
 
RESEARCH ARTICLE
Year : 2009  |  Volume : 1  |  Issue : 5  |  Page : 274-279

Anti-leukemia Activity of Methanolic Extracts of Lantana camara


1 Department of Biotechnology, Faculty of Applied Sciences, AIMST University, 08100 Semeling- Bedong, Kedah, Malaysia
2 Centre for Drug Research, University Science of Malaysia, 11800 Minden, Pulau Pinang, Malaysia

Correspondence Address:
Sasidharan Sreenivasan
Department of Biotechnology, Faculty of Applied Sciences, AIMST University, 08100 Semeling- Bedong, Kedah
Malaysia
Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

Anticancer effect of Lantana camara's root and leaf extracts against Jurkat leukemia cell line was investigated by MTT assay. These extracts had statistically similar antineoplastic property (root IC50, 328.36 53.08 μg/ml; leaf, 394.41 99.73 μg/ml; p > 0.1, n = 3), averagely 1/10 times as activity as carboplatin (IC50 34.83 3.60 μg/ml; p < 0.05, n = 3). Decreasing cytotoxicity at higher concentrations implied the existence of cytoprotective compounds. Morphological examinations indicated apoptosis induction as the mechanism of activity on Jurkat cells. In conclusion, L. camara's root and leaf extracts might be subjects for further fractionation and identification to find new anticancer agents.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed3199    
    Printed133    
    Emailed5    
    PDF Downloaded76    
    Comments [Add]    

Recommend this journal