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RESEARCH ARTICLE
Year : 2009  |  Volume : 1  |  Issue : 3  |  Page : 130-135

Cytotoxic acetogenins from Annona glabra cultivated in Egypt


1 Pharmacognosy Department, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt
2 Pharmacognosy Department, National Research Centre Dokki, 12622 Giza, Egypt
3 Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt
4 Tanning and Protein Department, National Research Centre Dokki, Giza, Egypt

Correspondence Address:
Ahmed Abdel-lateff
Pharmacognosy Department, Faculty of Pharmacy, Minia University, 61519 Minia
Egypt
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Source of Support: None, Conflict of Interest: None


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Bio-assay guided fraction of the methanolic extract of Annona glabra seeds (Annonaceae), cultivated in Egypt, revealed to the isolation of three bis-tetrahydrofuran acetogenins; squamocin-C (1) , squamocin-D (2) , and annonin I (3) . Compounds 1 and 2 were obtained as stereoisomeric mixture. All isolates were assayed for their cytotoxicity twards brine shrimp and five in vitro cancer cell lines (A549, HT29, MCF 7, RPMI, and U251), and showed significant activity The structures of all compounds were determined by interpretation of their NMR and MS analyses.


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