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RESEARCH ARTICLE
Year : 2009  |  Volume : 1  |  Issue : 2  |  Page : 43-52

Antifouling Alkaloids from Crinum augustum (Amaryllidaceae)


1 Pharmacognosy Department, Faculty of Pharmacy, Minia University, 61519 Minia, Egypt
2 Pharmacognosy Department, Faculty of Pharmacy, Assiut University, Egypt
3 Faculty of environmental earth science, Hokkaido University, Sapporo, 060-0810, Japan
4 Central Research Institute of Electric Power Industry, Biology Department, 1646 Abiko, Chiba 270-1194, Japan

Correspondence Address:
Ahmed Abdel-Lateff
Pharmacognosy Department, Faculty of Pharmacy, Minia University, 61519 Minia
Egypt
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Source of Support: None, Conflict of Interest: None


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Fractionation and purification of the ethanolic extract of the bulbs of Crinum augustum Rox. (Amaryllidaceae) cultivated in Egypt yielded five alkaloids 6-methoxy-crinamine (1) , crinamine (2) , buphanisine (3) , ungeremine (4) , and hippadine (5) ; two fatty acid derivatives: myristic acid ethyl ester (6) and palmitic acid ethyl ester (7) ; four terpenoidal and steroidal compounds: ursolic acid (8) , β-sitosterol-O- β glucopyranoside (9) and mixture of β-­sitosterol (10) and stigmasterol (11) . The structures of all compounds were determined by interpretation of their spectroscopic data; 1D ( 1 H and 13 C), 2D (HSQC, COSY, DQF, NOE and HMBC) NMR; MS and UV analyses. The compounds (1 -4) and (6-8) were tested towards biofouling activity using larvae of barnacle Balance amphitrie. Significant activities of 1, 2 and 3 with EC 50 1.8, 1.2 and 0.75 μg/mL respectively, were observed.


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