Home | About PR | Editorial board | Search | Ahead of print | Current Issue | Archives | Instructions | Subscribe | Advertise | Contact us |   Login 
Pharmacognosy Magazine
Search Article 
  
Advanced search 
 
RESEARCH ARTICLE
Year : 2009  |  Volume : 1  |  Issue : 1  |  Page : 1-3

Preliminary studies on lipoxygenase inhibitory activity of selected Malaysian medicinal plants


Medicinal Plants Programme, Forest Biotechnology Division, Forest Research Institute Malaysia, 52109 Kepong, Selangor, Malaysia

Correspondence Address:
M P Mazura
Medicinal Plants Programme, Forest Biotechnology Division, Forest Research Institute Malaysia, 52109 Kepong, Selangor
Malaysia
Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

A potential source for new lipoxygenase inhibitors is undoubtedly provided by the abundance of medicinal plants used in traditional medicine. As part of screening programme for biologically active plants, 20 extracts of different parts of 10 Malaysian medicinal plants belonging to four families were evaluated for their inhibitory activity on soybean 15-lipoxygenase (15-sLo). The leaves of Peronema canescens Jack. (Verbenaceae) were shown to be the most potent inhibitor with an IC 50 value of 25.64 μg/ml. While the extracts of P. canescens stem and Stereospermum fibricatum DC. (Bignonaceae) leaves were found to possess profound inhibitory activity with IC 50 values of 33.65 and 39.41 μg/ml, respectively. The methanol extracts obtained from Stenolobium stans (L.) D. Don (Bignonaceae) leaves and stems, Piper ribesioides Wall. (Piperaceae) stems and S. fibricatum stems were moderately active with IC 50 values ranging from 40 to 60 μg/ml. While the remaining samples showed low lipoxygenase inhibitory activity at concentration of 100 μg/ml.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1703    
    Printed150    
    Emailed1    
    PDF Downloaded93    
    Comments [Add]    

Recommend this journal